Methylation cycle blocks and glutathione deficiency
FOR GLUTATHIONE DEFICIENCY IN CHRONIC FATIGUE SYNDROME
Paul R Cheney MD, PhD
Fatigue 2000: International Conference, 23-24 April 1999
- Bounos G, Molson J. 1999 Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Med Hypoth 53:347-349.
- Droge W, Holm E. 1997 Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 11:1077-1089.
- An article in the journal Medical
Hypothesis proposed that glutathione, an antioxidant essential
for lymphocyte function, may be depleted in CFS patients. Glutathione
is needed for both the immune system and for aerobic muscular
contraction. The authors proposed that glutathione depletion by an
activated immune system also causes the muscular fatigue and myalgia
associated with CFS (Bounous et al. 1999).
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