patients with CFS were found to have sleep disorders which are likely to
contribute to the daytime fatigue and may also be important in the
etiology of the syndrome.
- S. Yamamoto, Y. Ouchi, H. Onoe, E. Yoshikawa, H. Tsukada, H. Takahashi, et al., "Reduction of Serotonin Transporters of Patients with Chronic Fatigue Syndrome," Brain Imaging, Vol. 15, No. 17, 2004, pp. 2571-2574. (Subgroup of CFS).
- A. R. Spitzer and M. Broadman, "Treatment of the Narcoleptiform Sleep Disorder in Chronic Fatigue Syndrome and Fibromyalgia with Sodium Oxybate," Pain Practice, Vol. 10, No. 1, 2010, pp. 54-59.
Spitzer and Broadman believe that many patients with ME/CFS and FM have a lesion in the ventral-lateral preoptic nucleus of hypothalamus, which is critical to initiating and maintaining sleep. This explains the sleep abnormalities in these illnesses.
- Van Hoof E, De Becker P, Lapp C, Cluydts R, De Meirleir K. Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. Am J Med Sci 2007;333(2):78–84.
- A. Kishi, B. H. Natelson, F. Togo, Z. R. Struzik, D. M. Rapoport and Y. Yamamoto, "Sleep Stage Transitions in Chronic Fatigue Syndrome Patients With or Without Fibromyalgia," Proceedings of the International Conference of the IEEE Engineering in Medicine and Biology Society, Vol. 1, 2010, pp. 5391-5394.
- Kishi A, Struzik ZR, Natelson BH, Togo F, Yamamoto Y. Dynamics of sleep stage
transitions in healthy humans and patients with chronic fatigue syndrome.
Am J Physiol
Regul Integr Comp Physiol
- Kishi A, Natelson BH, Togo F, Struzik ZR, Rapoport DM, Yamamoto Y. Sleep
dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.
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- Neu D, Mairesse O, Verbanck P, Le Bon O. Slow wave sleep in the chronically fatigued: power spectra distribution patterns in chronic fatigue syndrome and primary insomnia. Clin Neurophysiol 2015;126(10):1926–33.
- Decker MJ, Tabassum H, Lin JM, Reeves WC. Electroencephalographic correlates of
chronic fatigue syndrome.
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- Neu D, Mairesse O, Verbanck P, Linkowski P, Le Bon O. Non-REM sleep EEG power distribution in fatigue and sleepiness. J Psychosom Res 2014;76(4):286–91
- Jackson ML, Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review. J Clin Sleep Med 2012;8(6):719–28.
- A. N. Vgontzas, V. M. Zoumakis D. A. Papanicolaou, E. O. Bixler, P. Prolo, H. M. Lin, A. Vela-Bueno, A. Kales and G. P. Chrousos, "Chronic Insomnia is Associated with a Shift of Interleukin-6 and Tumor Necrosis Factor Secretion from Nighttime to Daytime," Metabolism, Vol. 51, 2002, pp. 887-892.
- Togo F, Natelson BH, Cherniack NS, FitzGibbons J, Garcon C, et al. Sleep structure and sleepiness in chronic fatigue syndrome with or without coexisting fibromyalgia. Arthritis Res Ther. 2008;10(3):R56.
- Sleep quality and psychological adjustment in chronic fatigue syndrome. Fossey M, Libman E, Bailes S, Baltzan M, Schondorf R, Amsel R, Fichten CS. J Behav Med. 2004 Dec;27(6):581-605.
- Sleep apnea in male patients with the fibromyalgia syndrome.
May KP, West SG, Baker MR, Everett DW. Am J Med. 1993 May;94(5):505-8.
survey of over 1000 patients with Fibromyalgia Syndrome (FMS) and
Chronic Fatigue Syndrome (CFS) showed that prior to their illness
fewer than 1% had disturbed sleep, whereas during their illness this
rose to over 90%."
Fibromyalgia Network Newsletters : October ‘90 through January
‘92 Compendium #2, January 1993, May 1993 Compendium, January
1994, July 1994. (the Newsleter is highly recommended for
information on FMS) Available from Fibromyalgia Network PO Box
31750, Tucson Arizona 85751-1750 USA
- Consequences of GABA depletion
- T. Doi, Y. Ueda, K. Nagatomo and L. J. Willmore, "Role of Glutamate and GABA Transporters in Development of Pentylenetetrazol-Kindling," Neurochemistry Research, Vol. 34, 2009, pp. 1324-1331.
- J. W. Winkelman, O. M. Buxton, J. E. Jensen, K. L. Benson, S. P. O'Connor, W. Wang and P. F. Renshaw, "Reduced Brain GABA in Primary Insomnia: Preliminary Data from 4T Proton Magnetic Resonance Spectroscopy (1H-MRS)," Sleep, Vol. 31, No. 11,2008, pp. 1499-1506.
- M. M. Halassa, C. Florian, T. Fellin, J. R. Munoz, S. Y. Lee, T. Abel, P. Haydon and M. G. Frank, "Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss," Neuron, Vol. 61, No. 2, 2009, pp. 213-219. doi:10.1016/j.neuron.2008.11.024
- Z. Y. Hong, Z. L. Huang, W. M. Qu, N. Eguchi, Y. Urade and O. Hayaishi, "An Adenosine A Receptor Agonist Induces Sleep by Increasing GABA Release in the Tuberomammillary Nucleus to Inhibit Histaminergic Systems in Rats," Journal of Neurochemistry, Vol. 92, 2005, pp. 1542-1549.
- J. Krueger, "The Brain that Never Fully Sleeps," Fibromyalgia Network, Vol. 85, 2009, pp. 12-15.
psychiatrist Dr Peter White, of London’s St Bartholomews’s
Hospital, states ' We know that two thirds of CFS patients have
sleep disorders ' ".
Quoted in the Ann Macintyre Interview in ‘INTERACTION’ (Journal
of ‘Action for ME’) No.16 Summer 1994 p20-24(highly recommended
for information onME) Available from PO Box 1302, Wells BA5 2WE,
has been found to be deficient in people with CFS(ME) and FMS, which
has a profound influence on sleep patterns and alterations in pain
Leon Chaitow, N.D., D.O., MRO, Senior Lecturer, University of
Chronic Fatigue Syndrome & Fibromyalgia: The Brain/Sleep
Vesselinova has been measuring blood and salivary melatonin levels
through the night and found them to be depressed in CFS patients.
This is to be expected since we know that hormone output from the
hypothalamus/pituitary/adrenal axis is abnormal, so the pineal, a
similar gland, is likely to be affected."
Dr. Sarah Myhill, Wales, UK. Dr Vesselinova is a doctor at
Lister Hospital in London, England.
sleep (periods of wakefulness throughout the sleep period) and lack
of deep-stage sleep are very common in CFS patients. True insomnia
(inability to fall asleep) is uncommon, although patients may have
delayed sleep onset because of a disrupted circadian rhythm.
Nancy Klimas, MD, University of Miami, CFS Basic Science Panel
meeting, March 16-18 in Reno, Nevada, USA. Eighteen CFS researchers
and clinicians participated on two panels to examine rehabilitation
strategies and basic science findings and make recommendations about
what and how knowledge about CFS could be applied by clinicians to
Byron Marshall, Editor; The Clinical and Scientific Basis of Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome; Nightingale Research
Foundation, Ottawa, Ontario, Canada, 1992.
PROBLEMS AND CHRONIC FATIGUE SYNDROME
Dr Richard Morris, Senior Lecturer in Psychiatry, University of
Fatigue 2000: International Conference, 23-24 April 1999