Substance P is elevated in ME patients

  • Research by Dr. Jay Goldstein shows that substance P is elevated in ME patients. Substance P is associated with inflammation, pain and brain disorders. This elevation of Substance P is very significant as it would explain the pains, inflammation, allergies, confusion and "brain fog" commonly found in ME/ CFS patients. Taken from Dr. Goldsteins book -
    "High levels of Substance P have repeatedly been found in CFS and may be responsible for the inappropriate post-exertional fatigue."
    "Gateing information is transmitted to your thalamus by a neurotransmitter called glutamate. Glutamate levels are abnormal in the CFS/FMS brain. Norepinephrine, a neurotransmitter that increases signal to noise ratio is low in the CFS/FMS brain, whereas substance P, a neurotransmitter which lowers signal to noise ratio is increased in the CFS/FMS brain. (Injection of substance P into the cerebrospinal fluid of healthy volunteers gives them diffuse body pain similar to that seen in FMS.)"
  • Hypothalamic-pituitary-adrenal axis imbalances can result in changes which are common in CFS (ME) and FMS including:
    - an increase in substance P (leading to more pain)
    - a decrease in growth hormone production
    - a decrease in energy production
    By Leon Chaitow, N.D., D.O., MRO, Senior Lecturer, University of Westminster
  • Yunus M . ‘Fibromyalgia and other functional syndromes’ Journal of Rheumatology 16(sup 19)69 1989

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