Human Herpes virus 6a or HHV-6a virus has been
consistently found in a majority of CFS patients in scientific research.
In addition, very high levels of this virus have been found in autopsies
of dead CFS patients. There is a consensus among top scientists,
researchers and doctors that HHV6a virus plays an important part in CFS. It may be a casuative factor, an opportunistic infection or a co-factor with other factors in the illness.
Paper - HHV6a and CFS
By HHV-6 Foundation, USA
destructive power of HHV-6a virus
HHV-6a is able to infect and kill
natural killer cells. Lusso, Paolo et al.; "Infection of Natural
Killer Cells by Human Herpesvirus 6"; Nature 349:533, February 7,
HHV-6a is able to infect and kill
CD4 (T4) cells. Lusso, P. et al.; "Productive Infection of
CD4-Positive and CD8-Positive Mature Human T Cell Populations and
Clones by Human Herpesvirus 6"; Journal of Immunology 147(2):685,
July 15, 1991.
HHV-6a can cause other immune
system cells (like CD8 cells) to express the CD4 cell surface antigen.
Lusso, P. et al; "Induction of CD4 and Susceptibility to HIV-1
Infection in Human CD98-Positive T Lymphocytes by Human Herpesvirus
6"; Nature 349:533, February 7, 1991.
HHV-6a destroys the B-cells of the
immune system at a rapid rate. This has been found in research carried
out by Robert Gallo MD of the NIH in the USA and research by
virologist Berch Henry, Nevada. This research is cited in the book 'Oslers
Web', by Hillary Johnson, Penguin Books 1997
HHV-6a can infect a wide variety of
organ tissues (besides immune system cells), including brain, spinal
cord, lung, lymph node, heart, bone marrow, liver, kidney, spleen,
tonsil, skeletal muscle, adrenal glands, pancreas, and thyroid. Knox,
K.K. and D.R. Carrigan; "Disseminated Active HHV-6a Infections in
Patients With AIDS"; The Lancet 343:577, March 5, 1994.
HHV-6a has been found to be closely
associated with Kaposi's sarcoma, and suggested as a possible
causitive agent of this "AIDS"-related cancer. Bovenzi, P.
et al.; "Human Herpesvirus 6 (Variant A) in Kaposi's
Sarcoma"; The Lancet 341:1288, May 15, 1993.
HHV-6a has been associated
with thrombocytopenia, a blood clotting disorder common in
"AIDS" patients. Kitamura, K. et al.; "Idiopathic
Thrombocytopenic Purpura After Human Herpesvirus 6 Infection";
The Lancet 344:830, September 17, 1994.
HHV-6a appears to cause
graft-versus-host disease, an immune disorder that develops after
transplant surgery (particularly after bone marrow transplantation).
Cone, R.W. et al.; "Human Herpesvirus 6 in Lung Tissue From
Patients With Pneumonitis After Bone Marrow Transplantation"; New
England Journal of Medicine 329:156, July 15, 1993.
HHV-6a can infect other species;
most notably, it has been found in 100 percent of some populations of
African green monkeys. Higashi, K. et al.; "Presence of Antibody
to HHV-6 In Monkeys"; J. Gen. Virol. 70:3171, 1989.
HHV-6a can cause fatal,
disseminated infections. Knox and Carrigan, op cit.
HHV-6a can cause fatal pneumonitis
(lung infection). R.W. Cone, op cit.
HHV-6a can cause fatal liver
failure. Asano, Y. et al.; "Fatal Fulminate Hepatitis in an
Infant With Human Herpesvirus-6 Infection"; The Lancet April 7,
HHV-6a can cause hepatitis, a
sometimes-fatal liver infection. Y. Asano et al., ibid.
HHV-6a is associated with the
development of brain lesions. Buchwald, D. et al.; "A Chronic, 'Postinfectious'
Fatigue Syndrome Associated With Benign Lymphoproliferation, B-Cell
Proliferation, and Active Replication of Human Herpesvirus-6";
Journal of Clinical Immunology 10:335, 1990.
HHV-6a is associated with a
particular type of skin rash, or dermatitis, that occurs frequently
following bone marrow transplantation. Michel, D. et al.; "Human
Herpesvirus 6 DNA in Exanthematous Skin in BMT Patient"; The
Lancet 344:686, September 3, 1994.
HHV-6a is spread through
saliva. Levy, J. et al.;"Frequent Isolation of HHV-6 From Saliva
and High Seroprevalence of the Virus in the Population"; The
Lancet, May 5, 1990.
HHV-6a has been found to be
associated with Hodgkin's lymphoma, acute lymphocytic leukemia,
African Burkitts lymphoma, and sarcoidosis, as well as
"AIDS" and Chronic Fatigue Syndrome. Lusso, P. et al.;
"In Vitro Cellular Tropism of Human B-Lymphotropic Virus(Human
Herpesvirus-6)"; Journal of Experimental Medicine 167:1659, May
The two variants of HHV-6, Variant
A and Variant B, appear to cause very different symptoms. Variant B
seems to be associated with mild, childhood infection and disease;
Variant A is found in immunocompromised adults with illnesses like
"AIDS," cancer, and Chronic Fatigue Syndrome. Dewhurst, S.W.
et al.; "Human Herpesvirus-6 (HHV-6) Variant B Accounts for the
Majority of Symptomatic Primary HHV-6 infections in a Population of
U.S. Infants"; Journal of Clinical Microbiology, February 1993.
HHV-6a's growth is stopped by the
experimental drug Ampligen. Ablashi, D.V. et al.; Ampligen Inhibits In
Vitro Replication of HHV-6"; Abstract from CFS conference,
Albany, NY, October 2-4, 1992
When HHV-6a's growth is stopped by
the experimental drug Ampligen in Chronic Fatigue Syndrome patients,
their symptoms resolve. (In a trial published in 1987, the same
appeared to be true for "AIDS" patients treated with
Ampligen.) Strayer, D.R. et al.; "A Controlled Clinical Trial
With a Specifically Configured RNA Drug, Poly(I):Poly(C12U), in
Chronic Fatigue Syndrome";Clinical Infectious Diseases, January
HHV-6a has been suggested as a
"cofactor" in the development of "AIDS." P. Lusso
and R.C. Gallo; "Human Herpesvirus 6 in AIDS"; The Lancet
343:555, March 5, 1994.
Effects of HHV-6a virus compiled by Neenyah Ostrom