Abnormal red blood cell structure

Scientific and Medical Evidence
- Listing of Research conducted worldwide section :

Abnormal red blood cell structure .
Scientific Findings in Primer for International Consensus Criteria (2012)

Some scientific studies have found abnormal red blood cell structure in ME patients. The details of this abnormality are outlined in the following research studies.

  • Red Blood cell structure
    • L. O. Simpson, 'The Role of Nondisocytic Erythrocytes in the Pathogenesis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome', The Clinical and Scientific Basis of ME/ CFS [Ottawa, Ontario: The Nightingale Research Foundation, 1992], p. 597
    • Mukherjee TM, Smith K, Maros K. Abnormal red-blood-cell morphology in myalgic en-cephalomyelitis. Lancet 1987;2:328-329.20. Simpson LO. Nondiscocytic erythrocytes inmyalgic encephalomyelitis. N Z Med J 1989;102:126-127.21.
    • Simpson LO, Murdoch JC, Herbison GP. Red cell shape changes following trigger finger fatigue in subjects with chronic tiredness and healthy controls. N Z Med J 1993;106:104-107
  • Test for Erythrocyte sedimentation rate. The rate is usually very low or zero in ME patients. Canadian clinician Byron Hyde reported in the fall 1989 issue of his newsletter to sufferers, “To my knowledge, there are only five diseases that have a pathological low sedimentation level: myalgic encephalomyelitis (ME also called CFS), sickle-cell anemia, hereditary sperocytosis, hyper-gammaglobulinemia, hyper-fibrogenemia.”


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